Polymorphism of gp15/400 allergen gene of W. bancrofti from different regions of India endemic for lymphatic filariasis.
Identifieur interne : 007152 ( Main/Exploration ); précédent : 007151; suivant : 007153Polymorphism of gp15/400 allergen gene of W. bancrofti from different regions of India endemic for lymphatic filariasis.
Auteurs : S L Hoti [Inde] ; R. Thangadurai ; K P Patra ; P K DasSource :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [ 1567-1348 ] ; 2007.
Descripteurs français
- KwdFr :
- Alignement de séquences, Allergènes (), Allergènes (génétique), Animaux, Anticorps antihelminthe, Antigènes d'helminthe (), Antigènes d'helminthe (génétique), Données de séquences moléculaires, Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Filariose lymphatique (épidémiologie), Glycoprotéines membranaires (), Glycoprotéines membranaires (génétique), Gènes d'helminthe, Inde (épidémiologie), Maladies endémiques, Phylogénie, Polymorphisme génétique, Protéines d'helminthes (), Protéines d'helminthes (génétique), Séquence d'acides aminés, Séquence nucléotidique, Wuchereria bancrofti (génétique), Wuchereria bancrofti (immunologie).
- MESH :
- génétique : Allergènes, Antigènes d'helminthe, Glycoprotéines membranaires, Protéines d'helminthes, Wuchereria bancrofti.
- immunologie : Filariose lymphatique, Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- épidémiologie : Filariose lymphatique, Inde.
- Alignement de séquences, Allergènes, Animaux, Anticorps antihelminthe, Antigènes d'helminthe, Données de séquences moléculaires, Glycoprotéines membranaires, Gènes d'helminthe, Maladies endémiques, Phylogénie, Polymorphisme génétique, Protéines d'helminthes, Séquence d'acides aminés, Séquence nucléotidique.
- Wicri :
- geographic : Inde.
English descriptors
- KwdEn :
- Allergens (chemistry), Allergens (genetics), Amino Acid Sequence, Animals, Antibodies, Helminth, Antigens, Helminth (chemistry), Antigens, Helminth (genetics), Base Sequence, Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Endemic Diseases, Genes, Helminth, Helminth Proteins (chemistry), Helminth Proteins (genetics), India (epidemiology), Membrane Glycoproteins (chemistry), Membrane Glycoproteins (genetics), Molecular Sequence Data, Phylogeny, Polymorphism, Genetic, Sequence Alignment, Wuchereria bancrofti (genetics), Wuchereria bancrofti (immunology).
- MESH :
- chemical , chemistry : Allergens, Antigens, Helminth, Helminth Proteins, Membrane Glycoproteins.
- chemical , genetics : Allergens, Antigens, Helminth, Helminth Proteins, Membrane Glycoproteins.
- geographic , epidemiology : India.
- epidemiology : Elephantiasis, Filarial.
- genetics : Wuchereria bancrofti.
- immunology : Elephantiasis, Filarial, Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- Amino Acid Sequence, Animals, Antibodies, Helminth, Base Sequence, Endemic Diseases, Genes, Helminth, Molecular Sequence Data, Phylogeny, Polymorphism, Genetic, Sequence Alignment.
Abstract
Nematode polyprotein allergens (NPA) are lipid binding/transport molecules that elicit elevated levels of IgE response in the infected host, leading to Th2 type of immune response. They also transport arachidonic acid and its metabolites that are known to be involved in the action of antifilarial drug, Diethylcarbamazine and hence are of great significance for the control of lymphatic filariasis. We investigated the polymorphism of gp15/400 polyprotein of 35 isolates of lymphatic filarial parasite Wuchereria bancrofti collected from different geographic locations of India. The repeat sub-unit of the gene was found to be highly conserved in all the isolates with only two nucleotide synonymous changes at positions 286 (A-G) and 337 (C-T). Since this molecule is highly conserved and has multifarious roles in the survival and pathogenesis of the parasite it has good potential as a target for drug, immunodulation tool and immunotherapy development.
DOI: 10.1016/j.meegid.2006.07.006
PubMed: 16971189
Affiliations:
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Le document en format XML
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nucléotidique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Inde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nematode polyprotein allergens (NPA) are lipid binding/transport molecules that elicit elevated levels of IgE response in the infected host, leading to Th2 type of immune response. They also transport arachidonic acid and its metabolites that are known to be involved in the action of antifilarial drug, Diethylcarbamazine and hence are of great significance for the control of lymphatic filariasis. We investigated the polymorphism of gp15/400 polyprotein of 35 isolates of lymphatic filarial parasite Wuchereria bancrofti collected from different geographic locations of India. The repeat sub-unit of the gene was found to be highly conserved in all the isolates with only two nucleotide synonymous changes at positions 286 (A-G) and 337 (C-T). Since this molecule is highly conserved and has multifarious roles in the survival and pathogenesis of the parasite it has good potential as a target for drug, immunodulation tool and immunotherapy development.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Das, P K" sort="Das, P K" uniqKey="Das P" first="P K" last="Das">P K Das</name><name sortKey="Patra, K P" sort="Patra, K P" uniqKey="Patra K" first="K P" last="Patra">K P Patra</name><name sortKey="Thangadurai, R" sort="Thangadurai, R" uniqKey="Thangadurai R" first="R" last="Thangadurai">R. Thangadurai</name></noCountry><country name="Inde"><noRegion><name sortKey="Hoti, S L" sort="Hoti, S L" uniqKey="Hoti S" first="S L" last="Hoti">S L Hoti</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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